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A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response

Suman Kumari Dabi Corresponding author sumandabi706@gmail.com Vardhman Mahavir Medical College and Safdarjung Hospital Delhi, New Delhi, India 0009-0002-4988-0566 , Insha Rafia Author Sub District Hospital Anta, Baran, Rajasthan, India

  1. 1 Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, New Delhi, India
  2. 2 Sub District Hospital, Anta, Baran, Rajasthan, India
Pages 70-78 Published 2 November 2026 DOI 10.65929/JSIA.2026.1.3.003 Rights held by the authors
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Abstract

Background: Neuromuscular blocking agents are routinely used to facilitate tracheal intubation. In some patients, however, avoiding these drugs may be desirable because of their adverse effects and the possibility of residual neuromuscular blockade. Combining sevoflurane with a lower dose of propofol may be one way of achieving adequate anesthetic depth while limiting the cardiovascular effects of a larger propofol dose.

Objectives: We compared combination of sevoflurane and propofol induction with propofol alone for intubation without a neuromuscular blocking agent. Intubating conditions, induction time, adverse events, and hemodynamic changes were assessed.

Methods: In this prospective randomized comparative study, 60 adults with American Society of Anesthesiologists physical status I or II who were scheduled for elective surgery were assigned to two groups. Group A received sevoflurane 4% and propofol 1.5 mg/kg, whereas Group B received propofol 3 mg/kg. Tracheal intubation was attempted 240 seconds after induction. Intubating conditions were graded with the Copenhagen Consensus Conference score, and heart rate and blood pressure variables were recorded serially.

Results: Acceptable intubating conditions were observed in 28 of 30 participants (93.3%) in Group A and 23 of 30 participants (76.7%) in Group B (p < 0.01). Combination of sevoflurane and propofol induction was associated with easier laryngoscopy, less coughing, fewer limb movements, and better preservation of systolic blood pressure and mean arterial pressure. Mean induction time was longer for combination of sevoflurane and propofol induction (185.60 ± 13.45 vs. 79.96 ± 10.17 seconds; p < 0.001), while the frequency of recorded induction-related adverse events did not differ significantly.

Conclusion: Sevoflurane 4% with propofol 1.5 mg/kg provided better intubating conditions and better preservation of early blood pressure than propofol 3 mg/kg alone in these elective surgical patients. The benefit was accompanied by a longer induction time.

Dates & metrics

Received
22 Aug 2026
Accepted
15 Oct 2026
Published
2 Nov 2026
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Keywords: Sevoflurane Propofol Tracheal intubation Muscle relaxant–free anesthesia

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How to cite this article

Dabi SK, Rafia I. A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response. J. Sci. Innov. Anesthesiol. 2026;1(3):70-78. doi:10.65929/JSIA.2026.1.3.003

RIS BibTeX EndNote

Dabi, S. K., & Rafia, I. (2026). A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response. Journal of Scientific Innovations in Anesthesiology, 1(3), 70-78. https://doi.org/10.65929/JSIA.2026.1.3.003

RIS BibTeX EndNote

Suman Kumari Dabi, and Insha Rafia. "A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response." Journal of Scientific Innovations in Anesthesiology, vol. 1, no. 3, 2026, pp. 70-78. https://doi.org/10.65929/JSIA.2026.1.3.003

RIS BibTeX EndNote

Suman Kumari Dabi, and Insha Rafia. "A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response." Journal of Scientific Innovations in Anesthesiology 1, no. 3 (2026): 70-78. https://doi.org/10.65929/JSIA.2026.1.3.003

RIS BibTeX EndNote

Dabi, S. K., and Rafia, I. (2026) 'A comparative study between combination of sevoflurane and propofol with propofol alone for intubating condition and hemodynamic response', Journal of Scientific Innovations in Anesthesiology, 1(3), pp. 70-78. https://doi.org/10.65929/JSIA.2026.1.3.003

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© 2026 the authors. Published by REVO Publication. This article is distributed under CC BY 4.0, which permits use and redistribution provided the original work is properly cited.